Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population
نویسندگان
چکیده
منابع مشابه
Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population.
We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People's Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the primers...
متن کاملThe Association of pre-mir-196a2 T/C Polymorphism and Risk of Gastric Cancer in Ardabil, Iran
Micro-RNAs are a large group of non-coding RNAs of 18-25 nucleotides in length. Polymorphisms in the human pre-mir-RNAs could change the efficiency of target cell and can also play a role in cell cycle regulation and cancer. The aim of this study is to investigate the association of rs11614913 T/C polymorphism with gastric cancer risk in Ardabil Province. In a case-control study, this polymorph...
متن کاملNo association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population
Objective(s): Accumulating evidence has demonstrated that miRNAs contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (GC). Recent studies focused on the four single nucleotide polymorphisms (SNPs) of pre-miRNAs including rs11614913, rs3746444, rs2910164, and rs2292832. It was suggested that these four SNPs were significantly associated with the risk ...
متن کاملHsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies
BACKGROUND MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS We conducted a meta-analysis of 15 studies ...
متن کاملThe Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies
Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for public...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2016
ISSN: 1676-5680
DOI: 10.4238/gmr.15027516